She is best known for her award winning talk show. it is the highest-rated program of its kind in history. to some she is the most influential woman worldwide. She grew up in Mississippi and was raised in inner-city Milwaukee. ... The first national broadcast of the Oprah Winfrey Show was in 1986. In the mid 1990s she focused her show on self improvement, spirituality and literature. She has been ranked as the richest African American of the 20th century, and the greatest ...